LYMPHOCYTE MEDIATED CYTOTOXICITY IN HUMAN RENAL ALLOTRANSPLANTATION
نویسندگان
چکیده
منابع مشابه
Lymphocyte-mediated Cytotoxicity in Vitro
The ability of antisera to suppress immune responses either in vivo or in vitro is well known. A variety of lymphocyte-target cell systems have been employed to demonstrate inhibition of cell-mediated immunity by antisera in vitro, and skin, tumor, and kidney graft survival have been prolonged by passively administered antiserum in vivo. An in vitro lymphocyte-tumor cell assay system was develo...
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Passive administration of anti-P-814 isoantiserum (IS) with P-815 mastocytoma was shown to augment the development of T-lymphocyte-mediated cytotoxicity (LMC). The LMC activity augmented by IS was specific to immunizing tumor cells, but required the simultaneous administration of P-815 tumor cells and anti-P-815 serum, suggesting that the antigen-antibody complex is involved in the development ...
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Granule-mediated cytotoxicity is the major mechanism for lymphocytes to kill viruses, intracellular bacteria and tumors. The cytotoxic granules move to the immunological synapse by exocytosis after recognition of a killer cell. The contents of the granules are delivered into target cells with the help of perforin by endocytosis. A group of serine protease granzymes cleave their critical substra...
متن کاملHuman lymphocyte antibody-dependent cell-mediated cytotoxicity (ADCC) toward human red blood cells.
Previous investigations involving mononuclear cell antibody-dependent cellmediated cytotoxicity (ADCC) toward human red cell (RBC) targets indicated that monocytes but not lymphocytes are able to produce erythrocyte lysis. We reexamined this reported insensitivity of human RBC to lymphocyte cytotoxicity using a variety of human RBC targets and a wide range of antisera to various erythrocyte ant...
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Sera from two patients with granulocytopenia associated with collagen vascular disease caused the destruction of normal human granulocytes by autologous lymphocytes in vitro. Granulocyte cytotoxicity was measured by the release of 51Cr during incubation with test sera and lymphocytes in microtiter plates. Between 8% and 46% granulocytoxicity was produced in granulocytes from 8 normal donors by ...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 1975
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.24.399